SCHEMBL7966547

SCHEMBL7966547

COC(=O)c1cccc2c1nc(C(=O)N(C)C)n2Cc1ccc(OC)cc1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSPO P30536 2/20 0.54
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
GLA P06280 1/20 0.45
GAA P10253 1/20 0.45
HPGD P15428 1/20 0.45
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
HSD17B10 Q99714 1/20 0.45
DCTPP1 Q9H773 1/20 0.44
P2RX7 Q99572 3/20 0.42
TBXA2R P21731 1/20 0.42
PTGS2 P35354 1/20 0.41
MAPT P10636 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7965376 0.91 TSPO (0.54) TSPOKDM4EALDH1A1DCTPP1TBXA2R
SCHEMBL7966864 0.87 PARP1 (0.51) TSPOKDM4EALDH1A1GLAGAA
SCHEMBL7427558 0.86 TSPO (0.47) TSPOKDM4EALDH1A1GLAGAA
SCHEMBL7483323 0.78 TSPO (0.47) TSPOKDM4EALDH1A1GLAGAA
SCHEMBL7954430 0.78 PARP1 (0.52) TSPOKDM4EALDH1A1GLAGAA
SCHEMBL28398222 0.73 L3MBTL1 (0.50) ALDH1A1GAA
SCHEMBL1201709 0.72 ALDH1A1 (0.47) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL8600049 0.71 KDM4E (0.51) TSPOKDM4EALDH1A1GLAGAA
SCHEMBL8601846 0.70 PPARG (0.48) TSPOKDM4EALDH1A1GLAGAA
SCHEMBL6953212 0.70 PPARG (0.50) KDM4EALDH1A1GLAGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed