Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13757018 | 0.83 | NOS2 (0.35) | HPGDALDH1A1KDRNOS2PTPN1 | |
| SCHEMBL7363172 | 0.80 | NOS2 (0.32) | NOS2 | |
| SCHEMBL31620125 | 0.80 | BCAT2 (0.44) | HSD17B10HPGDALDH1A1NOS2MAPT | |
| SCHEMBL31620126 | 0.76 | CA1 (0.38) | NOS2 | |
| SCHEMBL30485668 | 0.69 | PTGS2 (0.57) | HSD17B10HPGDALDH1A1BCL2L1KDR | |
| SCHEMBL5481383 | 0.68 | CA12 (0.31) | — | |
| SCHEMBL16104519 | 0.66 | ALOX15 (0.38) | HSD17B10ALOX15MAPT | |
| SCHEMBL20613159 | 0.66 | ALOX15 (0.38) | HSD17B10NOS2ALOX15MAPT | |
| SCHEMBL8469274 | 0.66 | ALOX15 (0.38) | HSD17B10ALOX15MAPTMEN1ALOX12 | |
| SCHEMBL28212019 | 0.66 | ALOX15 (0.38) | HSD17B10ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271253-B1 | CYCLOOXYGENASE INHIBITORS | G.D. SEARLE & CO. | 2001-08-07 | — | — | US | disclosed |