Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966073 | 0.82 | TRPV6 (0.41) | DRD4MAPTTDP1CCRL2CCR2 | |
| SCHEMBL7967371 | 0.81 | CCRL2 (0.43) | DRD4DRD2DRD3HSD11B1CCRL2 | |
| Hydrochloric Acid SCHEMBL7971160 | 0.80 | CCRL2 (0.43) | DRD4DRD2DRD3HSD11B1MAPT | |
| Carbamic Acid SCHEMBL10474895 | 0.78 | ALDH1A1 (0.46) | DRD4DRD2DRD3HSD11B1MAPT | |
| SCHEMBL30131210 | 0.74 | KMT2A (0.47) | DRD4DRD2DRD3HSD11B1MAPT | |
| SCHEMBL16803154 | 0.74 | KMT2A (0.47) | DRD4DRD2DRD3HSD11B1MAPT | |
| Hydrochloric Acid SCHEMBL30562858 | 0.73 | KMT2A (0.46) | DRD4DRD2DRD3HSD11B1MAPT | |
| SCHEMBL900225 | 0.72 | — | — | |
| SCHEMBL659325 | 0.72 | KDM4E (0.48) | DRD4DRD2DRD3HSD11B1MAPT | |
| SCHEMBL29448519 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |