Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.66 |
| ▸ | DRD2 | P14416 | 8/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670825 | 0.90 | DRD2 (0.59) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6961341 | 0.90 | DRD2 (0.74) | ADRA1DADRA1AADRA1BDRD2OPRM1 | |
| SCHEMBL7663181 | 0.90 | DRD2 (0.59) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7956108 | 0.87 | ADRA1D (0.68) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7702063 | 0.86 | ADRA1A (0.55) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7965434 | 0.86 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7566269 | 0.84 | DRD2 (0.63) | ADRA1DADRA1AADRA1BDRD2SIGMAR1 | |
| SCHEMBL14902481 | 0.83 | SIGMAR1 (0.56) | ADRA1DADRA1AADRA1BDRD2SIGMAR1 | |
| SCHEMBL14902477 | 0.82 | SIGMAR1 (0.60) | ADRA1DADRA1AADRA1BDRD2SIGMAR1 | |
| SCHEMBL7531578 | 0.81 | ADRA1A (0.59) | ADRA1DADRA1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274583-B1 | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. | 2001-08-14 | — | — | US | disclosed |
| US-5977115-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |