Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.44 |
| ▸ | F7 | P08709 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967465 | 0.86 | MAPT (0.56) | NAMPTMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7964485 | 0.81 | F7 (0.43) | NAMPTF7ALDH1A1MAPTHSD17B10 | |
| SCHEMBL7968531 | 0.77 | HSD17B10 (0.38) | NAMPTF7MEN1ALDH1A1MAPT | |
| SCHEMBL7970350 | 0.77 | MAPT (0.41) | MEN1ALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL7968477 | 0.77 | KDR (0.41) | MEN1ALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL7972098 | 0.75 | NAMPT (0.43) | NAMPTMEN1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL7969314 | 0.74 | KMT2A (0.56) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL7974449 | 0.74 | KDM4E (0.54) | ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL7969315 | 0.73 | CA2 (0.54) | MEN1ALDH1A1MAPTKMT2AF2 | |
| SCHEMBL7957018 | 0.73 | CSF1R (0.52) | MEN1ALDH1A1MAPTKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |