Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968918 | 0.85 | RAB9A (0.54) | GAAALDH1A1ALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL7967861 | 0.84 | RAB9A (0.51) | KDM4EGAAALDH1A1CXCR2SMN1; SMN2 | |
| SCHEMBL7975277 | 0.84 | RAB9A (0.55) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL7967421 | 0.83 | KMT2A (0.54) | KDM4EALDH1A1SMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL7966143 | 0.83 | HTT (0.53) | KDM4EGAASMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL7970330 | 0.82 | RAB9A (0.64) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7955588 | 0.82 | CA12 (0.53) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL7977635 | 0.82 | CA12 (0.51) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7967465 | 0.81 | MAPT (0.56) | GAAALDH1A1CA12CA1CA2 | |
| SCHEMBL7974448 | 0.81 | BDKRB1 (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |