Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969314 | 0.86 | KMT2A (0.56) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7966490 | 0.86 | NAMPT (0.47) | MAPTMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7957018 | 0.85 | CSF1R (0.52) | MAPTMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7970350 | 0.84 | MAPT (0.41) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7968477 | 0.84 | KDR (0.41) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL7968563 | 0.84 | RAB9A (0.55) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7966117 | 0.83 | RAF1 (0.48) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL7969958 | 0.82 | MEN1 (0.48) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7975298 | 0.82 | MAPT (0.55) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7955626 | 0.82 | MEN1 (0.55) | MAPTMEN1KMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |