Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957018 | 0.90 | CSF1R (0.52) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7968563 | 0.89 | RAB9A (0.55) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7966117 | 0.88 | RAF1 (0.48) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7955626 | 0.87 | MEN1 (0.55) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7969958 | 0.87 | MEN1 (0.48) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7975298 | 0.87 | MAPT (0.55) | KMT2AMEN1RAB9AALDH1A1TP53 | |
| SCHEMBL7967465 | 0.86 | MAPT (0.56) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7973003 | 0.85 | MEN1 (0.48) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7969315 | 0.85 | CA2 (0.54) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL7964851 | 0.84 | CNR1 (0.55) | KMT2AMEN1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |