SCHEMBL7966567

SCHEMBL7966567

CC(=O)Nc1ccc(C(F)(F)F)cc1Br

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.55
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA9 Q16790 1/20 0.54
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
ATM Q13315 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
ALDH1A1 P00352 2/20 0.50
RXFP1 Q9HBX9 2/20 0.48
KIF11 P52732 1/20 0.48
TOP2A P11388 3/20 0.47
DYRK1A Q13627 2/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
PTPN5 P54829 1/20 0.46
TSHR P16473 1/20 0.45
TAS2R14 Q9NYV8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7254538 0.87 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL2353155 0.85 MAPT (0.56) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL30394742 0.85 MAPT (0.56) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL17796948 0.85 TAS2R14 (0.48) NPSR1ALDH1A1KIF11MEN1KMT2A
SCHEMBL17827022 0.83 MEN1 (0.41) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL31245754 0.83 CYP1A2 (0.57) CYP1A2CYP2C9CYP2C19CYP3A4CYP2D6
SCHEMBL6063344 0.83 CYP1A2 (0.57) CYP1A2CYP2C9CYP2C19CYP3A4CYP2D6
SCHEMBL5544752 0.81 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19CYP3A4CYP2D6
SCHEMBL31434967 0.81 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL9185909 0.81 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10239869-B2 Sulfonamide compounds as voltage-gated sodium channel modulators LUPIN LIMITED (IN) 2019-03-26 US disclosed
CN-108349957-A Sulfonamide compounds as modulators of voltage-gated sodium channels 鲁平有限公司 2018-07-31 CN disclosed
EP-3344621-A1 SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS Lupin Limited (IN) 2018-07-11 EP disclosed
US-20180186777-A1 SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS LUPIN LIMITED (IN) 2018-07-05 US disclosed
WO-2017037682-A1 SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS LUPIN LIMITED (IN) 2017-03-09 WO disclosed
EP-2582680-A1 BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES Novartis AG (CH) 2013-04-24 EP disclosed
US-20130090342-A1 BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES NOVARTIS AG (CH) 2013-04-11 US disclosed
CN-102947274-A Biphenyl substituted 1, 3-dihydro-benzoimidazol-2-ylideneamine derivatives NOVARTIS AG 2013-02-27 CN disclosed
WO-2011157787-A1 BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES NOVARTIS AG (CH) 2011-12-22 WO disclosed
US-20110257137-A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE KALYPSYS, INC. (US) 2011-10-20 US disclosed
US-6300352-B1 FOR THERAPY OF ASTHMA ASTRAZENECA AB (SE) 2001-10-09 US disclosed
EP-0971892-A1 NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Astra Pharmaceuticals Limited (GB) 2000-01-19 EP disclosed
WO-1998042670-A1 NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ASTRA PHARMACEUTICALS LTD. (GB) 1998-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10239869-B2 Sulfonamide compounds as voltage-gated sodium channel modulators SCN7A, SCN1A, SCN5A CYP1A2 1590/4885CYP2C9 799/4885CYP2C19 1651/4885
US-20130090342-A1 BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES IGF1R, IGFBP1, IGFBP2 CYP1A2 430/4885CYP2C9 2887/4885CYP2C19 1681/4885
US-20110257137-A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE HRH4, HRH3, HRH2 CYP1A2 2609/4885CYP2C9 2484/4885CYP2C19 1732/4885
US-20180186777-A1 SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS SCN7A, SCN1A, SCN5A CYP1A2 1590/4885CYP2C9 799/4885CYP2C19 1651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.