Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883032 | 0.87 | CCR1 (0.48) | HTR1ASLC6A4TDP1HRH3DRD3 | |
| SCHEMBL7953373 | 0.86 | HTR1A (0.40) | HTR1ASLC6A4 | |
| SCHEMBL7953370 | 0.86 | HTR1A (0.56) | HTR1ASLC6A4 | |
| SCHEMBL7953366 | 0.85 | HTR1A (0.43) | HTR1ASLC6A4HTR1B | |
| SCHEMBL7887491 | 0.84 | HTR1A (0.44) | HTR1ASLC6A4HTR1DHTR1BHRH3 | |
| SCHEMBL7966189 | 0.83 | LTA4H (0.50) | HTR1ASLC6A4HRH3DRD3HTR2A | |
| SCHEMBL8397976 | 0.82 | HTR1A (0.45) | HTR1ASLC6A4HRH3DRD3HTR2A | |
| SCHEMBL6621730 | 0.81 | TDP1 (0.48) | HTR1ASLC6A4TDP1HRH3DRD3 | |
| SCHEMBL7962445 | 0.81 | HTR1A (0.42) | HTR1ASLC6A4TDP1HRH3DRD3 | |
| SCHEMBL7966346 | 0.81 | CYP2D6 (0.49) | SLC6A4HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |