Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUND | P17535 | 1/20 | 0.39 |
| ▸ | FOSB | P53539 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 10/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966598 | 0.80 | HTR2C (0.46) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL7967919 | 0.77 | JUND (0.39) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL6220554 | 0.77 | HTR1A (0.40) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7967131 | 0.76 | JUND (0.38) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL7969679 | 0.73 | MEN1 (0.52) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL1545124 | 0.70 | KDM4E (0.49) | HTR2CHTR1AMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL1838069 | 0.69 | KDM4E (0.51) | HTR2CHTR1AMEN1KMT2AKCNH2 | |
| SCHEMBL7965941 | 0.67 | PARP1 (0.54) | JUNDFOSBHTR2C | |
| SCHEMBL7965946 | 0.67 | CDK1 (0.40) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL7970948 | 0.67 | MEN1 (0.41) | JUNDFOSBHTR2CHTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |