Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 10/20 | 0.38 |
| ▸ | HTR2B | P41595 | 10/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952662 | 0.78 | HTR2C (0.60) | HTR2CHTR2BCDK5DYRK1ACDK5R1 | |
| SCHEMBL7962615 | 0.78 | HTR2C (0.42) | HTR2CHTR2BCDK5DYRK1ACDK5R1 | |
| SCHEMBL28607372 | 0.72 | DRD2 (0.43) | KDM4EALDH1A1MAPTMTNR1AIDO1 | |
| SCHEMBL7562950 | 0.68 | HTR1A (0.61) | KDM4EALDH1A1MAPTLMNAHTR2A | |
| SCHEMBL7960509 | 0.67 | HTR2A (0.42) | ALDH1A1MAPTHTR2CHTR2BCDK5 | |
| SCHEMBL7961261 | 0.66 | CDK5 (0.33) | KDM4EALDH1A1LMNACDK5DYRK1A | |
| SCHEMBL12278879 | 0.65 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL7951575 | 0.64 | HTR2C (0.46) | KDM4EALDH1A1MAPTLMNAHTR2C | |
| SCHEMBL11721149 | 0.64 | ACHE (0.40) | KDM4EALDH1A1MAPTLMNAHTR2C | |
| SCHEMBL7954149 | 0.64 | CDK5 (0.46) | KDM4EALDH1A1MAPTLMNAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |