Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967180 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2PLA2G1BATG4BNPSR1ALDH1A1 | |
| SCHEMBL7967171 | 0.75 | KMT2A (0.54) | KMT2A | |
| SCHEMBL7956817 | 0.73 | KEAP1 (0.47) | SMN1; SMN2NPSR1ALDH1A1TSHRLMNA | |
| SCHEMBL5260230 | 0.72 | F10 (0.52) | SMN1; SMN2F10USP2LMNAKMT2A | |
| SCHEMBL9335263 | 0.71 | MAPK1 (0.58) | F10NPSR1ALDH1A1HPGDKDM4E | |
| SCHEMBL13536500 | 0.70 | RAB9A (0.59) | SMN1; SMN2F10NPSR1ALDH1A1KDM4E | |
| SCHEMBL7967175 | 0.70 | ALDH1A1 (0.55) | SMN1; SMN2NPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL7956657 | 0.69 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL5649212 | 0.69 | MAPT (0.56) | SMN1; SMN2KDM4EMAPTHSD17B10KMT2A | |
| SCHEMBL27678416 | 0.69 | RAB9A (0.61) | SMN1; SMN2NPSR1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |