Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | F10 | P00742 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9332871 | 0.85 | MAPK1 (0.62) | MAPK1POLBF10KMT2AHSD17B10 | |
| SCHEMBL9332863 | 0.82 | KMT2A (0.51) | MAPK1POLBKMT2AHSD17B10MEN1 | |
| SCHEMBL9332899 | 0.78 | HTR1D (0.59) | POLBALDH1A1HTR1F | |
| SCHEMBL9567470 | 0.77 | HTR1D (0.53) | MAPK1POLBF10KMT2AHSD17B10 | |
| SCHEMBL5649484 | 0.75 | HDAC1 (0.58) | MAPK1F10KMT2AKDM4E | |
| SCHEMBL7805150 | 0.75 | HTR1D (0.77) | MAPK1POLBKMT2AHSD17B10MEN1 | |
| SCHEMBL675442 | 0.75 | HTR1D (0.71) | MAPK1KMT2AHSD17B10MEN1ALDH1A1 | |
| SCHEMBL8759265 | 0.73 | LMNA (0.61) | MAPK1KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL8985995 | 0.73 | HTR1D (0.74) | POLBKMT2AHSD17B10MEN1ALDH1A1 | |
| SCHEMBL5647682 | 0.71 | POLB (0.54) | MAPK1POLBKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5358948-A | Psychological, nervous system disorders | GLAXCO GROUP LIMITED (GB) | 1994-10-25 | — | — | US | disclosed |
| WO-1993006084-A1 | BENZANILIDE DERIVATIVES AS 5-HT1D ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
| EP-0533267-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |