Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | CTSE | P14091 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6802425 | 0.89 | ALDH1A1 (0.55) | ALDH1A1BACE1CTSDCTSESTS | |
| Water SCHEMBL8370294 | 0.87 | ALDH1A1 (0.40) | ALDH1A1BACE1CTSDCTSESTS | |
| SCHEMBL5240524 | 0.87 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL16874679 | 0.84 | ALDH1A1 (0.51) | ALDH1A1BACE1CTSDCTSESTS | |
| SCHEMBL8398896 | 0.83 | YAP1 (0.49) | GPR119 | |
| SCHEMBL15595077 | 0.83 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5759621 | 0.82 | KDM4E (0.41) | ALDH1A1BACE1CTSDCTSESTS | |
| SCHEMBL6159582 | 0.82 | LMNA (0.49) | ALDH1A1BACE1CTSDCTSESTS | |
| SCHEMBL16874616 | 0.82 | L3MBTL1 (0.50) | ALDH1A1BACE1CTSDCTSESTS | |
| SCHEMBL6311972 | 0.81 | ALDH1A1 (0.46) | ALDH1A1BACE1CTSDCTSESTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |