Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893391 | 0.87 | KDM4E (0.50) | POLBKDM4ETRPM8MEN1KMT2A | |
| SCHEMBL7978882 | 0.85 | TP53 (0.49) | TRPM8MEN1KMT2ATSHRNPC1 | |
| SCHEMBL19512684 | 0.84 | NPSR1 (0.47) | POLBKDM4EMEN1KMT2ATSHR | |
| SCHEMBL7982461 | 0.83 | ALDH1A1 (0.48) | POLBKDM4ETRPM8MEN1KMT2A | |
| SCHEMBL7982503 | 0.82 | S100A4 (0.48) | POLBKDM4EMEN1KMT2ATSHR | |
| SCHEMBL229105 | 0.81 | HTT (0.53) | POLBKDM4EMEN1KMT2ATSHR | |
| SCHEMBL7968760 | 0.79 | MEN1 (0.58) | POLBKDM4ETRPM8MEN1KMT2A | |
| SCHEMBL31393785 | 0.79 | KMT2A (0.66) | POLBKDM4ETRPM8MEN1KMT2A | |
| SCHEMBL6340651 | 0.79 | HTT (0.47) | POLBKDM4EMEN1KMT2ATSHR | |
| SCHEMBL28332018 | 0.79 | POLB (0.55) | POLBTRPM8MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |