Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30285745 | 0.82 | TP53 (0.47) | TP53SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL7985644 | 0.80 | TRPM8 (0.42) | TP53SMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL30285811 | 0.79 | MEN1 (0.45) | TP53SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL30285884 | 0.79 | ALDH1A1 (0.46) | TP53SMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL29005766 | 0.79 | MEN1 (0.45) | TP53SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL29005482 | 0.79 | ALDH1A1 (0.46) | TP53SMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL19512684 | 0.79 | NPSR1 (0.47) | TP53KDM4EHTTLMNAALDH1A1 | |
| SCHEMBL4613837 | 0.79 | MAPT (0.44) | TP53SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL7978952 | 0.79 | ALDH1A1 (0.45) | TP53SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL29005449 | 0.78 | HTT (0.44) | TP53SMN1; SMN2HTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1252068-A | 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions containing the same | JAPAN TOBACCO INC (JP) | 2000-05-03 | — | — | CN | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |