Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969416 | 0.82 | NPC1 (0.36) | NPC1RAB9AKMT2ASSTR4AAK1 | |
| SCHEMBL9223865 | 0.75 | NPC1 (0.35) | NPC1RAB9AALDH1A1KMT2ASSTR4 | |
| SCHEMBL2429665 | 0.73 | NPC1 (0.45) | NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL2424191 | 0.71 | PAX8 (0.35) | NPC1RAB9AALDH1A1SSTR4AAK1 | |
| SCHEMBL970408 | 0.70 | NPC1 (0.49) | NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL5838309 | 0.70 | NPC1 (0.42) | NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL5164159 | 0.70 | NPC1 (0.40) | NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL22372221 | 0.68 | NPC1 (0.44) | NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL23367084 | 0.67 | L3MBTL1 (0.41) | NPC1RAB9AALDH1A1 | |
| Dimethylformamide SCHEMBL15323070 | 0.66 | NPC1 (0.53) | NPC1RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297241-B1 | TREATMENT OF DISORDERS WHICH ARE RESPONSIVE TO THE OPENING OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS. | BRISTOL-MYERS SQUIBB COMPANY | 2001-10-02 | — | — | US | disclosed |