Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223865 | 0.84 | NPC1 (0.35) | NPC1RAB9AGBA1PDK2CACNA1G | |
| SCHEMBL7969408 | 0.82 | NPC1 (0.35) | NPC1RAB9ASSTR4AAK1KMT2A | |
| SCHEMBL10260946 | 0.74 | HDAC6 (0.40) | GBA1PDK2CACNA1GCACNA1BCACNA1C | |
| SCHEMBL2429665 | 0.74 | NPC1 (0.45) | NPC1RAB9AKMT2A | |
| SCHEMBL2424191 | 0.72 | PAX8 (0.35) | NPC1RAB9ACACNA1GCACNA1BCACNA1C | |
| SCHEMBL970408 | 0.71 | NPC1 (0.49) | NPC1RAB9AKMT2A | |
| SCHEMBL5838309 | 0.71 | NPC1 (0.42) | NPC1RAB9AKMT2A | |
| SCHEMBL22372037 | 0.71 | NPC1 (0.40) | NPC1RAB9AHRH4KMT2A | |
| SCHEMBL5164159 | 0.71 | NPC1 (0.40) | NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL16984510 | 0.70 | SIRT6 (0.40) | GBA1PDK2CACNA1GCACNA1BCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297241-B1 | TREATMENT OF DISORDERS WHICH ARE RESPONSIVE TO THE OPENING OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS. | BRISTOL-MYERS SQUIBB COMPANY | 2001-10-02 | — | — | US | disclosed |