Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983002 | 0.94 | LCK (0.46) | FGFR1SRCLCKTLR7PDE2A | |
| SCHEMBL7969762 | 0.84 | LCK (0.46) | FGFR1SRCLCKTLR7PDE2A | |
| SCHEMBL7983558 | 0.80 | LCK (0.39) | FGFR1SRCLCKTLR7PDE2A | |
| SCHEMBL7984047 | 0.78 | LCK (0.37) | FGFR1SRCLCKTLR7PDE2A | |
| SCHEMBL7983062 | 0.78 | LCK (0.50) | FGFR1LCKTLR7PDE2A | |
| SCHEMBL7969613 | 0.75 | PDE2A (0.38) | LCKPDE2ASMN1; SMN2PDE10A | |
| SCHEMBL7983240 | 0.75 | PDE2A (0.43) | FGFR1LCKPDE2AKDM4EPDE10A | |
| SCHEMBL7969906 | 0.74 | LCK (0.37) | LCKPDE2A | |
| SCHEMBL7979955 | 0.74 | LCK (0.54) | FGFR1LCKPDE2A | |
| SCHEMBL7981250 | 0.73 | PDE2A (0.40) | FGFR1SRCLCKTLR7PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |