Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 4/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980082 | 0.89 | ROCK2 (0.45) | ROCK2ROCK1 | |
| SCHEMBL7983240 | 0.89 | PDE2A (0.43) | PDE2APDE10AABL1LCKFGFR1 | |
| SCHEMBL7981250 | 0.87 | PDE2A (0.40) | PDE2APDE10AABL1LCKFGFR1 | |
| SCHEMBL7983693 | 0.84 | LCK (0.43) | PDE2AABL1LCKFGFR1SRC | |
| SCHEMBL7969762 | 0.82 | LCK (0.46) | PDE2APDE10AABL1LCKFGFR1 | |
| SCHEMBL7981780 | 0.81 | NPC1 (0.43) | PDE2AFGFR1 | |
| SCHEMBL7982709 | 0.80 | LCK (0.53) | PDE2ALCKFGFR1WEE1KDR | |
| SCHEMBL7983214 | 0.79 | LCK (0.51) | LCKFGFR1SRCWEE1KDR | |
| SCHEMBL7981128 | 0.79 | LCK (0.54) | LCKFGFR1SRCWEE1KDR | |
| SCHEMBL7983558 | 0.79 | LCK (0.39) | PDE2ALCKFGFR1SRCTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |