Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.33 |
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | TACR2 | P21452 | 3/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953304 | 0.90 | OPRL1 (0.38) | OPRL1HTR1AOPRM1ABCB1LTA4H | |
| SCHEMBL7965200 | 0.88 | LTA4H (0.38) | OPRL1HTR1ADRD2DRD3DRD4 | |
| SCHEMBL7968938 | 0.86 | OPRL1 (0.38) | OPRL1HTR1ADRD2DRD3OPRM1 | |
| SCHEMBL7962733 | 0.86 | ABCB1 (0.39) | OPRL1HTR1ADRD2DRD3ABCB1 | |
| SCHEMBL7969773 | 0.85 | ABCB1 (0.47) | ABCB1 | |
| SCHEMBL7966030 | 0.84 | ABCB1 (0.38) | OPRL1HTR1ADRD2OPRM1ABCB1 | |
| SCHEMBL7953684 | 0.84 | OPRL1 (0.36) | OPRL1HTR1AOPRM1ABCB1LTA4H | |
| SCHEMBL7953964 | 0.83 | HTR1A (0.40) | OPRL1HTR1ADRD2DRD3OPRM1 | |
| SCHEMBL7953354 | 0.83 | ALPL (0.36) | OPRL1HTR1ADRD2DRD3HTR2A | |
| SCHEMBL8132545 | 0.83 | NOTUM (0.33) | OPRL1HTR1ADRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |