Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980571 | 0.93 | HTT (0.54) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7984003 | 0.86 | ERN1 (0.65) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9181819 | 0.85 | TUBB4A (0.55) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8759768 | 0.85 | HTT (0.54) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29900125 | 0.84 | ERN1 (0.52) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8759774 | 0.83 | MAPT (0.55) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8997635 | 0.82 | HTT (0.51) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8427571 | 0.80 | ALDH1A1 (0.57) | MAPTHPGDSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7970089 | 0.79 | HTT (0.53) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7222505 | 0.79 | MAPT (0.64) | HTTTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |