Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981518 | 0.94 | P2RX4 (0.56) | SRCP2RX4CYP1A2ALDH1A1MAPT | |
| SCHEMBL7987262 | 0.85 | SRC (0.50) | SRCCYP1A2ALDH1A1MAPTLMNA | |
| SCHEMBL7988065 | 0.79 | SRC (0.54) | SRCCYP1A2ALDH1A1MAPTLMNA | |
| SCHEMBL7980254 | 0.76 | SRC (1.00) | SRCP2RX4ALDH1A1MAPTLMNA | |
| SCHEMBL11835810 | 0.76 | AKR1C3 (0.63) | CYP1A2PTGS1PTGS2PDE4APDE4B | |
| SCHEMBL7983836 | 0.72 | SRC (0.55) | SRCALDH1A1MAPTHTTNPC1 | |
| SCHEMBL2461597 | 0.72 | PTGS2 (0.86) | CYP1A2MAPTLMNACYP2D6CYP2C9 | |
| SCHEMBL5809374 | 0.72 | PTGS2 (0.57) | SRCCYP1A2ALDH1A1MAPTLMNA | |
| SCHEMBL7971057 | 0.72 | SRC (0.52) | SRCALDH1A1MAPTLMNAPTGS1 | |
| SCHEMBL7981595 | 0.71 | SRC (0.55) | SRCMAPTLMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |