Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.44 |
| ▸ | PRKACG | P22612 | 3/20 | 0.44 |
| ▸ | PRKACB | P22694 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988065 | 0.93 | SRC (0.54) | SRCCYP1A2ALDH1A1PRKACAPRKACG | |
| SCHEMBL7971057 | 0.88 | SRC (0.52) | SRCALDH1A1PRKACAPRKACGPRKACB | |
| SCHEMBL7983836 | 0.87 | SRC (0.55) | SRCALDH1A1PRKACAPRKACGPRKACB | |
| SCHEMBL7981595 | 0.87 | SRC (0.55) | SRCPRKACAPRKACGPRKACBNPC1 | |
| SCHEMBL7981392 | 0.85 | SRC (0.61) | SRCCYP1A2ALDH1A1NPC1RAB9A | |
| SCHEMBL7970249 | 0.85 | SRC (0.57) | SRCPRKACAPRKACGPRKACBLMNA | |
| SCHEMBL7983604 | 0.84 | SRC (0.58) | SRCALDH1A1PRKACAPRKACGPRKACB | |
| SCHEMBL7981518 | 0.80 | P2RX4 (0.56) | SRCCYP1A2ALDH1A1MAPTLMNA | |
| SCHEMBL7970472 | 0.80 | SRC (0.55) | SRCALDH1A1PRKACAPRKACGPRKACB | |
| SCHEMBL7970608 | 0.72 | SRC (0.50) | SRCALDH1A1MAPTCYP19A1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |