Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7970406 | 0.78 | GBA1 (0.38) | SIGMAR1MTNR1AMTNR1B | |
| SCHEMBL5373262 | 0.70 | ALDH1A1 (0.56) | CYP2C9CYP2C19HTR2BMAPK14KMT2A | |
| SCHEMBL5205363 | 0.69 | F2 (0.44) | KMT2AMEN1POLB | |
| SCHEMBL5206103 | 0.69 | OPRM1 (0.49) | KDM4ELMNACCR5 | |
| SCHEMBL5203441 | 0.69 | DRD2 (0.46) | CYP2C9CYP2C19MAPK14KMT2AKDM4E | |
| SCHEMBL5206501 | 0.66 | OPRM1 (0.49) | KMT2AMEN1POLBCCR3 | |
| SCHEMBL3813779 | 0.65 | HRH3 (0.49) | CYP2C9CYP2C19HTR2BMAPK14KMT2A | |
| SCHEMBL8485315 | 0.64 | ALDH1A1 (0.51) | CYP2C9CYP2C19HTR2BMAPK14KMT2A | |
| SCHEMBL28115774 | 0.63 | CYP1A2 (0.38) | MTNR1AMTNR1BALDH1A1HPGDLMNA | |
| SCHEMBL5202187 | 0.63 | SLC2A1 (0.53) | CYP2C9CYP2C19HTR2BMAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |