Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.39 |
| ▸ | PDE2A | O00408 | 10/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969906 | 0.95 | LCK (0.37) | LCKPDE2A | |
| SCHEMBL7969613 | 0.91 | PDE2A (0.38) | LCKPDE2APDE10A | |
| SCHEMBL7982210 | 0.88 | MAP3K8 (0.42) | LCKFGFR1ABL1 | |
| SCHEMBL7983062 | 0.88 | LCK (0.50) | LCKPDE2AFGFR1KDR | |
| SCHEMBL7983558 | 0.84 | LCK (0.39) | LCKPDE2AFGFR1 | |
| SCHEMBL7983240 | 0.84 | PDE2A (0.43) | LCKPDE2APDE10AFGFR1ABL1 | |
| SCHEMBL7979955 | 0.83 | LCK (0.54) | LCKPDE2AFGFR1KDR | |
| SCHEMBL7980189 | 0.83 | CAMK2D (0.44) | LCKFGFR1KDR | |
| SCHEMBL7984047 | 0.82 | LCK (0.37) | LCKPDE2AFGFR1 | |
| SCHEMBL7983648 | 0.81 | LCK (0.57) | LCKPDE2AFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |