Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983712 | 0.89 | PDE2A (0.39) | PDE2APDE10AFGFR1LCKABL1 | |
| SCHEMBL7969906 | 0.85 | LCK (0.37) | PDE2ALCKKMT2A | |
| SCHEMBL7983558 | 0.85 | LCK (0.39) | PDE2AFGFR1LCK | |
| SCHEMBL7984047 | 0.84 | LCK (0.37) | PDE2AFGFR1LCKMAPK14 | |
| SCHEMBL7970474 | 0.84 | LCK (0.39) | PDE2APDE10AFGFR1LCKABL1 | |
| SCHEMBL7983062 | 0.82 | LCK (0.50) | PDE2AFGFR1LCK | |
| SCHEMBL7982210 | 0.82 | MAP3K8 (0.42) | FGFR1LCKALDH1A1KDM4EABL1 | |
| SCHEMBL7983002 | 0.81 | LCK (0.46) | PDE2AFGFR1LCKKMT2A | |
| SCHEMBL7980189 | 0.80 | CAMK2D (0.44) | FGFR1LCKKMT2AGFER | |
| SCHEMBL7980082 | 0.80 | ROCK2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |