Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 10/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970474 | 0.91 | LCK (0.39) | PDE2APDE10ALCK | |
| SCHEMBL7983671 | 0.88 | MAP3K8 (0.46) | PDE2ALMNAMAPK1HTT | |
| SCHEMBL7969906 | 0.87 | LCK (0.37) | PDE2ALCK | |
| SCHEMBL7979828 | 0.84 | LCK (0.48) | PDE2APDE10ALCK | |
| SCHEMBL7970503 | 0.83 | CAMK2D (0.43) | PDE2ALCK | |
| SCHEMBL7969691 | 0.82 | NPC1 (0.39) | PDE2APDE10ACDK9LCK | |
| SCHEMBL7987029 | 0.82 | LCK (0.45) | PDE2APDE10ACDK9LCK | |
| SCHEMBL7983613 | 0.82 | LCK (0.51) | PDE2ALMNAMAPK1LCK | |
| SCHEMBL7982991 | 0.82 | LCK (0.43) | PDE2APDE10ACDK9LCK | |
| SCHEMBL7983672 | 0.81 | FGFR1 (0.53) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |