Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 6/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879570 | 0.89 | NFE2L2 (0.52) | NFE2L2GRM4KDM1AHDAC1HDAC6 | |
| SCHEMBL2879571 | 0.89 | NFE2L2 (0.52) | NFE2L2GRM4KDM1AHDAC1HDAC6 | |
| SCHEMBL27761312 | 0.87 | NR3C1 (0.40) | LOXL2NR3C1PPARGNFE2L2GRM4 | |
| SCHEMBL12185927 | 0.86 | KDM1A (0.55) | LOXL2GRM4KDM1AMAPTNPC1 | |
| SCHEMBL16319244 | 0.83 | NFE2L2 (0.56) | NFE2L2GRM4NPC1SMN1; SMN2 | |
| SCHEMBL16319242 | 0.83 | NFE2L2 (0.56) | NFE2L2GRM4NPC1SMN1; SMN2 | |
| SCHEMBL7422694 | 0.82 | ENPP2 (0.41) | LOXL2NR3C1PPARGGRM4KDM1A | |
| SCHEMBL12955070 | 0.82 | NR3C1 (0.40) | LOXL2NR3C1PPARGGRM4KDM1A | |
| SCHEMBL7434021 | 0.82 | ENPP2 (0.41) | LOXL2NR3C1PPARGGRM4KDM1A | |
| SCHEMBL2641826 | 0.82 | CYP1A2 (0.61) | NFE2L2KDM1AHDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214847-B1 | TREATMENT OF COGNITIVE OR NEUROLOGICAL DYSFUNCTION | DUPONT PHARMACEUTICALS COMPANY | 2001-04-10 | — | — | US | disclosed |