Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422029 | 0.88 | TSHR (0.36) | DHODH | |
| SCHEMBL7562864 | 0.83 | STING1 (0.41) | DHODHMAPTHDAC6 | |
| SCHEMBL7970926 | 0.73 | DHODH (0.46) | DHODHACKR3MAPT | |
| SCHEMBL6866628 | 0.66 | DHODH (0.54) | DHODH | |
| SCHEMBL29281090 | 0.66 | DHODH (0.57) | DHODH | |
| SCHEMBL5604152 | 0.65 | MEP1B (0.46) | — | |
| SCHEMBL5603701 | 0.64 | ALDH1A1 (0.43) | — | |
| SCHEMBL29308340 | 0.64 | DHODH (0.51) | DHODHMAPT | |
| SCHEMBL7763429 | 0.64 | MEN1 (0.41) | — | |
| SCHEMBL2397307 | 0.64 | DHODH (0.54) | DHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |