Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 6/20 | 0.44 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27583638 | 0.76 | ADAMTS4 (0.73) | ADAMTS4MMP9MMP13MMP2MMP8 | |
| SCHEMBL6501557 | 0.76 | ADAMTS4 (0.73) | ADAMTS4MMP9MMP13MMP2MMP8 | |
| SCHEMBL7449822 | 0.75 | ITGA4 (0.48) | ADAMTS4ITGA4ITGB1MMP9MMP13 | |
| SCHEMBL6500456 | 0.75 | ADAMTS4 (0.71) | ADAMTS4MMP9MMP13MMP2MMP8 | |
| SCHEMBL7386889 | 0.75 | ITGB1 (1.00) | ADAMTS4ITGA4ITGB1HTT | |
| SCHEMBL7448688 | 0.74 | ITGB1 (0.48) | ADAMTS4ITGA4ITGB1ALDH1A1CA2 | |
| SCHEMBL16004826 | 0.74 | ADAMTS4 (0.57) | ADAMTS4MMP9MMP13MMP2MMP8 | |
| SCHEMBL7921230 | 0.73 | ITGA4 (0.42) | ADAMTS4ITGA4ITGB1ACLYS1PR1 | |
| SCHEMBL6510024 | 0.73 | ADAMTS4 (0.68) | ADAMTS4MMP9MMP13MMP2MMP8 | |
| SCHEMBL7361218 | 0.72 | ADAMTS5 (0.73) | ITGA4MMP2ADAMTS5ACLYS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271252-B1 | ASTHMA THERAPY, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS,MULTIPLE SCLEROSIS, AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-08-07 | — | — | US | disclosed |