Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 3/20 | 0.33 |
| ▸ | CCND3 | P30281 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140116 | 0.83 | CA12 (0.36) | CHEK1CDK7CDK2CDK4CCNA2 | |
| SCHEMBL20307797 | 0.81 | F9 (0.47) | F9F10F11F7CHEK1 | |
| SCHEMBL7973898 | 0.78 | ALDH1A1 (0.44) | F9F10F11F7CHEK1 | |
| SCHEMBL7961139 | 0.76 | F9 (0.47) | F9F10F11F7CHEK1 | |
| SCHEMBL7971260 | 0.74 | F9 (0.45) | F9F10F11F7MAPK1 | |
| SCHEMBL7978374 | 0.74 | F9 (0.54) | F9F10F11F7MAPK1 | |
| SCHEMBL7974859 | 0.73 | F9 (0.68) | F9F10F11F7MAPK1 | |
| SCHEMBL20307773 | 0.72 | F9 (0.43) | F9F10F11F7CHEK1 | |
| SCHEMBL10172729 | 0.70 | PTGDR2 (0.36) | KDM4EALDH1A1BRAF | |
| SCHEMBL7974191 | 0.70 | F10 (0.55) | F9F10F11F7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |