Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961139 | 0.85 | F9 (0.47) | F9F10F11F7MMP2 | |
| SCHEMBL10172625 | 0.83 | MMP2 (0.45) | MMP2MMP9MMP8MMP13CHEK2 | |
| SCHEMBL7973898 | 0.81 | ALDH1A1 (0.44) | F9F10F11F7MAPT | |
| SCHEMBL20307797 | 0.79 | F9 (0.47) | F9F10F11F7CHEK2 | |
| SCHEMBL7974859 | 0.77 | F9 (0.68) | F9F10F11F7CHEK2 | |
| SCHEMBL7971254 | 0.74 | F9 (0.41) | F9F10F11F7ALDH1A1 | |
| SCHEMBL7974191 | 0.72 | F10 (0.55) | F9F10F11F7CHEK2 | |
| SCHEMBL20307773 | 0.72 | F9 (0.43) | F9F10F11F7CHEK2 | |
| SCHEMBL7978374 | 0.72 | F9 (0.54) | F9F10F11F7CHEK2 | |
| SCHEMBL7960247 | 0.70 | F9 (0.60) | F9F10F11F7CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |