Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971643 | 0.82 | HTR1A (0.43) | HTR1ADRD2TP53LMNAALDH1A1 | |
| SCHEMBL6958771 | 0.77 | HTR1A (0.50) | HTR1ADRD2TP53LMNAALDH1A1 | |
| SCHEMBL8100872 | 0.68 | HTR1A (0.35) | HTR1ADRD2TP53MAPKAPK2MAPT | |
| SCHEMBL6960098 | 0.65 | ALDH1A1 (0.51) | HTR1ADRD2LMNAALDH1A1KDM4E | |
| SCHEMBL6958794 | 0.65 | HTR1A (0.48) | HTR1ADRD2LMNAALDH1A1 | |
| SCHEMBL8110287 | 0.63 | LMNA (0.34) | LMNAALDH1A1MAPTGAA | |
| Hydrochloric Acid SCHEMBL6953846 | 0.61 | HTR1A (0.49) | HTR1ADRD2LMNAALDH1A1 | |
| SCHEMBL9336316 | 0.61 | HTR1A (0.58) | HTR1ADRD2TP53LMNAALDH1A1 | |
| Oxalic Acid SCHEMBL9334144 | 0.59 | HTR1A (0.56) | HTR1ADRD2TP53LMNAALDH1A1 | |
| SCHEMBL6959602 | 0.58 | RAB9A (0.47) | TP53LMNAALDH1A1ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221884-B1 | Carboxamides useful as 5-HT1F agonists | ELI LILLY AND COMPANY | 2001-04-24 | — | — | US | disclosed |