Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | EBP | Q15125 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.32 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.31 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968378 | 0.84 | L3MBTL1 (0.40) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 | |
| SCHEMBL5236598 | 0.79 | EBP (0.59) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 | |
| SCHEMBL5753392 | 0.79 | L3MBTL1 (0.44) | L3MBTL1EBPSIGMAR1CYP3A4 | |
| SCHEMBL7966884 | 0.78 | EBP (0.47) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 | |
| SCHEMBL7129611 | 0.78 | L3MBTL1 (0.43) | L3MBTL1EBPSIGMAR1CYP2C19MEN1 | |
| SCHEMBL7956602 | 0.77 | SIGMAR1 (0.58) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 | |
| SCHEMBL7956311 | 0.77 | EBP (0.46) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 | |
| SCHEMBL5227349 | 0.77 | L3MBTL1 (0.44) | L3MBTL1EBPSIGMAR1MEN1CHRM2 | |
| SCHEMBL7956207 | 0.76 | SIGMAR1 (0.48) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 | |
| SCHEMBL7956313 | 0.76 | SIGMAR1 (0.73) | L3MBTL1EBPSIGMAR1CYP3A4ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265439-B1 | Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives | G.D. SEARLE & CO. | 2001-07-24 | — | — | US | disclosed |
| US-5451604-A | Useful in organ transplant surgery | G. D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | disclosed |