Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557895 | 0.97 | ALDH1A1 (0.70) | ALDH1A1ALOX15TSHRHSD17B10DRD2 | |
| SCHEMBL2562376 | 0.96 | ALDH1A1 (0.68) | ALDH1A1ALOX15TSHRHSD17B10DRD2 | |
| SCHEMBL31232864 | 0.92 | ALDH1A1 (0.73) | ALDH1A1ALOX15TSHRHSD17B10DRD2 | |
| SCHEMBL10836350 | 0.90 | ALDH1A1 (0.60) | ALDH1A1ALOX15TSHRHSD17B10DRD2 | |
| SCHEMBL4715710 | 0.87 | HTR1A (0.68) | ALDH1A1DRD2HTR1AMAOB | |
| SCHEMBL18770805 | 0.87 | DRD2 (0.82) | ALDH1A1DRD2HTR2ASIGMAR1MEN1 | |
| SCHEMBL1275567 | 0.85 | HTR1A (0.68) | ALDH1A1DRD2HTR1AMAOB | |
| SCHEMBL13469510 | 0.84 | HTR1A (0.79) | DRD2HTR1AMAOB | |
| SCHEMBL4709916 | 0.83 | MAOB (0.64) | ALDH1A1DRD2HTR1AMAOB | |
| SCHEMBL13278990 | 0.82 | HTR1A (0.68) | DRD2HTR1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1223659-A | Fused imidazopyridine derivatives as antihyperlipidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |
| US-4585773-A | DIURETIC, HYPOTENSIVE | BRISTOL-MYERS COMPANY (US) | 1986-04-29 | — | — | US | disclosed |