Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969974 | 0.78 | MAPK1 (0.38) | MEN1KMT2AGAA | |
| SCHEMBL29053190 | 0.72 | MEN1 (0.47) | MEN1KMT2APOLBHSD17B10PIN1 | |
| SCHEMBL29487580 | 0.70 | HTR2C (0.62) | MEN1KMT2APOLLL3MBTL1HTR2C | |
| SCHEMBL5290305 | 0.70 | HTR2C (0.62) | MEN1KMT2APOLLL3MBTL1HTR2C | |
| SCHEMBL12635245 | 0.67 | ADRA1A (0.55) | MEN1KMT2APKMPOLLL3MBTL1 | |
| SCHEMBL30129583 | 0.67 | ADRA1A (0.55) | MEN1KMT2APKMPOLLL3MBTL1 | |
| SCHEMBL12635239 | 0.67 | ADRA1A (0.55) | MEN1KMT2APKMPOLLL3MBTL1 | |
| SCHEMBL12667873 | 0.67 | ADRA1A (0.55) | MEN1KMT2APKMPOLLL3MBTL1 | |
| SCHEMBL7987943 | 0.67 | PKM (0.34) | HSD17B10PKMKDM4EALDH1A1HPGD | |
| SCHEMBL26918402 | 0.66 | HTR2C (0.57) | MEN1KMT2APOLLHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218406-B1 | AS ANTITUMOR AND ANTILEUKEMIC AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-04-17 | — | — | US | disclosed |
| US-6124465-A | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments | RHONE-POULENC S.A. (FR) | 2000-09-26 | — | — | US | disclosed |
| US-6013662-A | ANTITUMOR, ANTICARCINOGENIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 2000-01-11 | — | — | US | disclosed |