Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12635245 | 1.00 | ADRA1A (0.55) | ADRA1AADRA1DHTR2CMAP1LC3BPDE4A | |
| SCHEMBL30129583 | 1.00 | ADRA1A (0.55) | ADRA1AADRA1DHTR2CMAP1LC3BPDE4A | |
| SCHEMBL12667873 | 1.00 | ADRA1A (0.55) | ADRA1AADRA1DHTR2CMAP1LC3BPDE4A | |
| SCHEMBL824116 | 0.92 | HTR2C (0.53) | ADRA1AADRA1DHTR2CMAP1LC3BPDE4A | |
| SCHEMBL34463201 | 0.92 | HTR2C (0.53) | ADRA1AADRA1DHTR2CMAP1LC3BPDE4A | |
| SCHEMBL29487580 | 0.90 | HTR2C (0.62) | ADRA1AADRA1DHTR2CMAP1LC3BMEN1 | |
| SCHEMBL5290305 | 0.90 | HTR2C (0.62) | ADRA1AADRA1DHTR2CMAP1LC3BMEN1 | |
| SCHEMBL26918402 | 0.85 | HTR2C (0.57) | ADRA1AADRA1DHTR2CMAP1LC3BPDE4A | |
| SCHEMBL643845 | 0.83 | MAP1LC3B (0.57) | ADRA1AADRA1DHTR2CMAP1LC3BMEN1 | |
| SCHEMBL30384404 | 0.83 | MAP1LC3B (0.54) | ADRA1AADRA1DHTR2CMAP1LC3BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105389-A1 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same | OCERA THERAPEUTICS, INC. | 2011-05-05 | — | — | US | disclosed |
| US-20110105389-A1 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same | OCERA THERAPEUTICS, INC. | 2011-05-05 | — | — | US | disclosed |
| WO-2011053821-A1 | MACROCYCLIC GHRELIN RECEPTOR ANTAGONISTS AND INVERSE AGONISTS AND METHODS OF USING THE SAME | TRANZYME PHARMA, INC. (US) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105389-A1 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same | GHSR, GHRHR, GIPR | ADRA1A 262/4885ADRA1D 300/4885HTR2C 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.