Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307720 | 0.92 | CYP19A1 (0.63) | CYP19A1MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL7977426 | 0.89 | CNR1 (0.48) | MAPTSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL10140271 | 0.88 | CNR1 (0.47) | MAPTSMN1; SMN2POLBALDH1A1NPSR1 | |
| SCHEMBL10140554 | 0.85 | ALDH1A1 (0.43) | CYP19A1MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL16258926 | 0.83 | CYP19A1 (0.60) | CYP19A1MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3793270 | 0.75 | MAPT (0.51) | CYP19A1MAPTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL25307190 | 0.75 | ALDH1A1 (0.58) | MAPTSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL10140278 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBNPSR1CNR1CNR2 | |
| SCHEMBL16377892 | 0.73 | PTGER4 (0.56) | MAPTSMN1; SMN2POLBALDH1A1CNR1 | |
| SCHEMBL9925003 | 0.73 | PTGDR2 (0.54) | MAPTSMN1; SMN2POLBALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| EP-2805939-A1 | Heterocyclic compounds as factor IXA inhibitors. | Merck Sharp & Dohme Corp. (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |