Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7633403 | 0.86 | L3MBTL1 (0.54) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| SCHEMBL13351790 | 0.83 | EGFR (0.46) | KDM4EEGFRERBB2KMT2ALMNA | |
| SCHEMBL8215730 | 0.76 | L3MBTL1 (0.51) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| SCHEMBL10732366 | 0.76 | HTT (0.48) | L3MBTL1KDM4EGLAALDH1A1LMNA | |
| SCHEMBL14948252 | 0.74 | L3MBTL1 (0.49) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| SCHEMBL502785 | 0.74 | CYP4F2 (0.63) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL14935731 | 0.73 | L3MBTL1 (0.47) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| SCHEMBL7636374 | 0.72 | KMT2A (0.54) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| SCHEMBL7635254 | 0.71 | LMNA (0.48) | L3MBTL1KDM4EGLAEGFRERBB2 | |
| SCHEMBL5536942 | 0.70 | CYP4F2 (0.58) | L3MBTL1KDM4EGLAEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |