Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967292 | 0.91 | MAPK1 (0.41) | MAPK1MAPTTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7958101 | 0.86 | RAB9A (0.47) | MAPTTDP1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7967717 | 0.81 | OPRD1 (0.47) | — | |
| SCHEMBL7957969 | 0.77 | RAB9A (0.48) | MAPTTDP1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4906987 | 0.72 | SMN1; SMN2 (0.53) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL31578670 | 0.72 | ALDH1A1 (0.60) | MAPK1MAPTALDH1A1LMNAGAA | |
| SCHEMBL11157975 | 0.72 | MEN1 (0.62) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4190201 | 0.72 | DRD2 (0.50) | MAPK1MAPTTDP1SMN1; SMN2LMNA | |
| SCHEMBL2073208 | 0.72 | MAPT (0.65) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL6311629 | 0.72 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200978-B1 | FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |