Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985373 | 0.99 | PDE5A (0.49) | XDHPDE5AALDH1A1MEN1KMT2A | |
| SCHEMBL7988249 | 0.95 | PDE5A (0.50) | XDHPDE5AALDH1A1MEN1KMT2A | |
| SCHEMBL7984998 | 0.90 | PDE5A (0.52) | PDE5AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7988488 | 0.85 | BRD4 (0.50) | XDHPDE5AALDH1A1MEN1KMT2A | |
| SCHEMBL7984240 | 0.85 | LMNA (0.58) | PDE5AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7974613 | 0.82 | CNOT7 (0.49) | PDE5AALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL7974067 | 0.81 | ADORA2B (0.46) | XDHPDE5AALDH1A1MEN1KMT2A | |
| SCHEMBL7985382 | 0.80 | ADORA2B (0.46) | PDE5AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7984495 | 0.80 | HPGD (0.47) | XDHPDE5AALDH1A1MEN1KMT2A | |
| SCHEMBL7975265 | 0.79 | SMN1; SMN2 (0.61) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |