Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326509 | 0.91 | LMNA (0.51) | LMNAALDH1A1MEN1KMT2ATACR1 | |
| SCHEMBL7831653 | 0.88 | PKM (0.53) | L3MBTL1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7831649 | 0.87 | GPR119 (0.49) | MEN1KMT2ATACR1KDM1AGPR119 | |
| SCHEMBL7841164 | 0.85 | POLB (0.45) | L3MBTL1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7839366 | 0.84 | GPR119 (0.48) | L3MBTL1ALDH1A1MEN1KMT2ATACR1 | |
| SCHEMBL22014536 | 0.84 | TACR1 (0.48) | ALDH1A1MEN1KMT2ATACR1GPR119 | |
| SCHEMBL965515 | 0.84 | LMNA (0.62) | L3MBTL1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL30289438 | 0.83 | TACR1 (0.47) | MEN1KMT2ATACR1GPR119NPSR1 | |
| SCHEMBL2374896 | 0.82 | PKM (0.55) | L3MBTL1LMNAMEN1KMT2AGPR119 | |
| SCHEMBL28226580 | 0.82 | OPRD1 (0.45) | LMNAMEN1KMT2ATACR1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |