Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MYLK | Q15746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357245 | 0.83 | ALDH1A1 (0.67) | KDM4EALDH1A1SMN1; SMN2GLO1LMNA | |
| SCHEMBL822366 | 0.82 | NPSR1 (0.69) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL6978300 | 0.81 | POLB (0.56) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL1379633 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL28338196 | 0.78 | SCN9A (0.53) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL1667129 | 0.78 | KDM4E (0.75) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL1094173 | 0.73 | POLB (0.55) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL332569 | 0.73 | TSHR (0.70) | KDM4EALDH1A1NPSR1SLC40A1G6PD | |
| SCHEMBL1377807 | 0.73 | HSD11B1 (0.54) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL24554275 | 0.71 | KDM4E (0.77) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081335-A1 | PYRIMIDINE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | claimed |