Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30209688 | 0.90 | HSD11B1 (0.74) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL13962914 | 0.86 | ALDH1A1 (0.74) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL18560174 | 0.86 | KDM4E (0.71) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3296049 | 0.86 | KDM4E (0.67) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| Sulfapyridine SCHEMBL44219 | 0.86 | SMN1; SMN2 (1.00) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8067195 | 0.86 | KDM4E (0.71) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL15215659 | 0.86 | POLB (0.72) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| Sulfapyridine SCHEMBL29438089 | 0.86 | SMN1; SMN2 (1.00) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| Sulfapyridine SCHEMBL668918 | 0.84 | SMN1; SMN2 (0.97) | KDM4ELMNASMN1; SMN2POLBALDH1A1 | |
| Sulfapyridine SCHEMBL11706483 | 0.84 | SMN1; SMN2 (0.97) | KDM4ELMNASMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115521248-B | Chiral alpha-aminomalonate compound containing N-pyridyl benzenesulfonamide, preparation method and application | 贵州理工学院 | 2024-04-05 | — | — | CN | claimed |
| CN-115521248-A | Chiral alpha-amino malonate compounds containing N-pyridyl benzene sulfonamide, and preparation method and application thereof | 贵州理工学院 | 2022-12-27 | — | — | CN | claimed |
| CN-115124459-A | Method for selectively nitrating N- (2-pyridyl) benzene sulfonamide compound | 宁波大学 | 2022-09-30 | — | — | CN | claimed |
| WO-2022046682-A1 | BROMODOMAIN AND EXTRA TERMINAL DOMAIN (BET) INHIBITOR COMPOSITIONS AND METHODS THEREOF FOR USE AS ANTI-AGING AGENTS | MDI BIOLOGICAL LABORATORY (US) | 2022-03-03 | — | — | WO | claimed |
| CN-103739600-B | A kind of method of synthesis of cyclic amidine compound | SUN YAT-SEN UNIVERSITY (CN) | 2016-02-03 | — | — | CN | claimed |
| CN-103739600-A | A novel method for synthesizing cycle amidine compound | UNIV SUN YAT SEN | 2014-04-23 | — | — | CN | claimed |
| US-8354407-B2 | 2-anilino-4-(heterocyclic)amino-pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-10 | — | — | US | claimed |
| CN-101506175-A | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | claimed |
| EP-2054392-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | Boehringer Ingelheim International GmbH (DE) | 2009-05-06 | — | — | EP | claimed |
| WO-2007146981-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | claimed |
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | DJUNG JANE F | 2007-12-20 | — | — | US | claimed |
| EP-1599477-A1 | SULFONAMIDE SUBSTITUTED XANTHINE DERIVATIVES FOR USE AS PEPCK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-30 | — | — | EP | claimed |
| WO-2004074288-A1 | SULFONAMIDE SUBSTITUTED XANTHINE DERIVATIVES FOR USE AS PEPCK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-02 | — | — | WO | claimed |
| EP-3713918-B1 | SULFASALAZINE SALTS, PRODUCTION PROCESSES AND USES | MEDAC GES FUER KLINISCHE SPEZIALPRAEPARATE MBH (DE) | 2025-07-23 | — | — | EP | disclosed |
| US-12274706-B2 | Pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production process and use | MEDAC GESELLSCHAFT FUER KLINISCHE (DE) | 2025-04-15 | — | — | US | disclosed |
| CN-1088918-A | The salicylic acid compounds of new replacement | KABI PHARMACIA AB (SE) | 1994-07-06 | — | — | CN | disclosed |
| US-4186019-A | SULFONAMIDOPYRIDINES, SILVER HALIDE | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1980-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | PRKCA, PRKCG, PRKCH | KDM4E 981/4885LMNA 1437/4885SMN1; SMN2 3836/4885 |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | PRKCA, PRKCG, PRKCH | KDM4E 981/4885LMNA 1437/4885SMN1; SMN2 3836/4885 |
| US-12274706-B2 | Pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production process and use | SI, SOST, SLC10A2 | KDM4E 4632/4885LMNA 4858/4885SMN1; SMN2 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.