Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989153 | 0.81 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1RAB9ALMNA | |
| SCHEMBL5066564 | 0.73 | CLK4 (0.48) | ALDH1A1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL7986965 | 0.73 | MAPT (0.41) | MEN1KMT2AALDH1A1RAB9ALMNA | |
| SCHEMBL7988190 | 0.72 | PDE10A (0.45) | MEN1KMT2ARAB9AHTTL3MBTL1 | |
| SCHEMBL1415469 | 0.68 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1RAB9ALMNA | |
| SCHEMBL5263862 | 0.68 | DYRK1A (0.46) | MAPK9MAPK14TDP1PIK3CAPIK3CG | |
| SCHEMBL7985834 | 0.68 | MEN1 (0.43) | MEN1KMT2AALDH1A1RAB9AHTT | |
| SCHEMBL4965891 | 0.65 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1RAB9ALMNA | |
| SCHEMBL8864442 | 0.64 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1RAB9AHTT | |
| SCHEMBL4196981 | 0.63 | CCR1 (0.54) | MAPK14CCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001042243-A2 | PROTEIN KINASE INHIBITORS | ADVANCED MEDICINE, INC. (US) | 2001-06-14 | — | — | WO | claimed |
| WO-2001042243-A2 | PROTEIN KINASE INHIBITORS | ADVANCED MEDICINE, INC. (US) | 2001-06-14 | — | — | WO | disclosed |