Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133056 | 0.87 | HSD11B1 (0.48) | HSD11B1L3MBTL1ALDH1A1POLBHTT | |
| SCHEMBL28428330 | 0.87 | HSD11B1 (0.34) | HSD11B1L3MBTL1ALDH1A1POLBHTT | |
| SCHEMBL21439790 | 0.84 | — | — | |
| SCHEMBL3644747 | 0.80 | HSD11B1 (0.43) | HSD11B1L3MBTL1ALDH1A1HTTKDM4E | |
| SCHEMBL24856804 | 0.78 | HSD11B1 (0.38) | HSD11B1L3MBTL1ALDH1A1POLBHTT | |
| SCHEMBL23021653 | 0.76 | GLA (0.37) | HSD11B1L3MBTL1ALDH1A1HTTCRHBP | |
| SCHEMBL24202563 | 0.76 | HSD11B1 (0.37) | HSD11B1L3MBTL1ALDH1A1POLBHTT | |
| SCHEMBL4168964 | 0.76 | HSD11B1 (0.36) | HSD11B1L3MBTL1ALDH1A1HTTNPSR1 | |
| SCHEMBL4580828 | 0.74 | SMN1; SMN2 (0.43) | HSD11B1L3MBTL1ALDH1A1HTTCRHBP | |
| SCHEMBL24197088 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187780-B1 | ANTIDEPRESSANTS, ANTIASTHMATIC AGENTS; MIGRAINE | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-02-13 | — | — | US | disclosed |
| US-5445762-A | Stabilized complex ligands and their use in liquid crystal displays | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-29 | — | — | US | disclosed |