Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | PARN | O95453 | 1/20 | 0.38 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985538 | 0.89 | SMN1; SMN2 (0.43) | DPP4SMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL7985801 | 0.88 | CXCR2 (0.41) | DPP4SMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL7974646 | 0.86 | MAPK14 (0.47) | DPP4SMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL7975267 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1HPGDGAAKMT2A | |
| SCHEMBL7975122 | 0.83 | GAA (0.46) | SMN1; SMN2ALDH1A1HPGDGAAP2RX7 | |
| SCHEMBL7984459 | 0.82 | NR1H2 (0.43) | SMN1; SMN2ALDH1A1HPGDGAAKMT2A | |
| SCHEMBL7985492 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1HPGDKMT2APARN | |
| SCHEMBL7988558 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HPGDGAAKMT2A | |
| SCHEMBL7991405 | 0.80 | CYP11B1 (0.45) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPK1 | |
| SCHEMBL7974441 | 0.80 | GRK2 (0.43) | SMN1; SMN2ALDH1A1HPGDGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |