Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 6/20 | 0.46 |
| ▸ | FABP3 | P05413 | 2/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162818 | 0.80 | FABP4 (0.67) | FABP4FABP3FABP5GAAALDH1A1 | |
| Tetrazole SCHEMBL5862695 | 0.79 | FABP4 (0.46) | FABP4FABP3FABP5GAAALDH1A1 | |
| SCHEMBL16737021 | 0.71 | — | — | |
| SCHEMBL8675650 | 0.70 | FABP4 (0.53) | FABP4FABP3FABP5GAAALDH1A1 | |
| SCHEMBL21297046 | 0.69 | FABP4 (0.51) | FABP4FABP3FABP5GAAALDH1A1 | |
| SCHEMBL9014752 | 0.69 | FABP4 (0.47) | FABP4FABP3FABP5GAAALDH1A1 | |
| SCHEMBL27874557 | 0.67 | — | — | |
| SCHEMBL8989764 | 0.67 | FABP4 (0.69) | FABP4FABP3FABP5GAAALDH1A1 | |
| Isopropylbenzene SCHEMBL29288252 | 0.67 | SLC6A2 (0.38) | GAAALDH1A1TDP1 | |
| SCHEMBL8172825 | 0.67 | FABP4 (0.58) | FABP4FABP3FABP5GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281201-B1 | REPLACEMENT OF THE ADENINE MOIETY IN THE (2'-5')OLIGOADENYLATE TRIMER CORE WITH 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE OR WITH N6-(BENZYLAMINO)PURINE (ADEBN)-MOIETIES HAS RESULTED IN A NEW GROUP OF INHIBITORS OF HIV-1 REPLICATION. | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2001-08-28 | — | — | US | disclosed |